Mr and Mrs Smith

The film opens with John (Brad Pitt) and Jane Smith (Angelina Jolie) answering questions during marriage counselling. The couple has been married for "five or six" years, but their marriage is suffering to the point that they cannot remember the last time they had sex. They tell the story of their first meeting in Bogotá, Colombia, where they met while both were secretly on the run from Colombian authorities. They quickly fell in love and were married. John later states that Jane "looked like Christmas morning" to him on the day they met.

In reality, John and Jane are both skilled assassins working for different firms, both among the best in their field. Each is concealing their true profession from their spouse. Under these cover stories, John and Jane balance their apparently mundane marriage – which both of them find after a few years to be growing dull and suffocating – with their secretive work. When both are assigned to kill Benjamin "The Tank" Danz (Adam Brody), they encounter each other on the job and botch the hit. Believing each had been sent to stop the other from completing their mission, they seek to discover and eliminate the other.

After a few "mild" attempts on each other's lives, fueled by a mutual sense of betrayal, the marital spat culminates in a high-octane fight in the Smith house. After a long, evenly-matched fight, with their house shot to shambles, they wind up with guns in each other's faces. John balks, and lays his gun down; Jane finds she cannot shoot her spouse either, and both succumb to their love instead. Mr. and Mrs. Smith reunite and rediscover each other.

The newly-rekindled Smith partnership is quickly threatened by their employers, who have now decided to eliminate the couple. John's best friend and coworker, Eddie (Vince Vaughn), turns down a bounty of $400,000 for each Smith, but John and Jane find themselves under fire from an army of assassins. Fending off an attack which blows up their house, the Smiths steal their neighbor's minivan and successfully destroy three pursuing armored cars of attackers, all while bickering over their fighting styles and newly-discovered personal secrets.